寻求合作
[供] 德国大学提供用于诊断和治疗炎性疾病的手段和方法
合作类型:技术     行业类别: 生物科学与健康     国家:德国
发布时间:2018年03月20日     过期时间:2020年12月14日     点击数:9

技术转移办事处代表著名的德国大学。小儿风湿免疫科的研究小组发现,S100A12-TLR4相互作用的结构性理解允许特异性靶向TLR4在自体炎症中的激活。 这对受复杂遗传性自身炎症疾病影响的患者是有益的。他们希望签订许可证或合作研究协议。

A technology transfer office represents a known German university. The research team of the Department of Pediatric Rheumatology and Imunology found that the structural understanding of the S100A12-TLR4 interaction allows to specifically target TLR4-activation in autoinflammation. This can be beneficial for patients affected by complex genetic autoinflammatory diseases. They want to enter into a license or cooperation research agreement.

 

Description     

The Department of Pediatric Rheumatology and Imunology of the University Children´s Hospital is researching on chronic inflammatory diseases. Depending on pattern recognition receptors (PRRs) such as toll like receptors (TLRs), the innate immune system can be activated by pathogen associated molecular patterns (PAMPs) like lipopolysaccharides (LPS) or by damage associated molecular patterns (DAMPs; also termed 'alarmins'). DAMPs are endogenous molecules such as cellular proteins, lipids or nucleic acids. DAMP-functions are well described for the members of the calgranulin protein family, S100A8/A9 and S100A12, which are highly overexpressed in certain autoinflammatory diseases where their non-classical cellular release or spontaneous hypersecretion correlates with disease causing genotype and coincides with local as well as systemic inflammatory activity.

They previously demonstrated human monocytes to respond to S100A12 stimulation in an exclusively TLR4-dependent manner and have now found that binding of S100A12 to TLR4 and, in particular, the TLR4-dependent inflammatory stimulation requires the organization of the protein into a hexameric ring structure consisting of six similar building blocks. While current anti inflammatory therapies target cytokines which can arise downstream of TLR4-activation, our structural understanding of the S100A12-TLR4 interaction now allows to specifically target TLR4-activation by an endogenous molecule as an inherent disease perpetuating phenomenon in autoinflammation. They are now looking for licensees to enter into a license agreement.

 

Type and Role of Partner Sought    

Type of partner sought: industry (SME, MNE)

Specific area of activity of the partner: licensing, product development, research cooperation, product production, marketing, development of therapeutics or diagnostic tools

【供】180049 TODE20171211003

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