寻求合作
[求] 意大利研发机构寻对流感病毒识别靶细胞的分子机制知识开发感兴趣的研究组织
合作类型:技术     行业类别: 生物科学与健康     国家:意大利
发布时间:2018年08月23日     过期时间:2021年05月19日     点击数:13

意大利一家在调研甲型流感病毒方面具有丰富经验的研发机构正在寻找研究合作协议的合作伙伴。甲型流感病毒在人类及禽类养殖场中广泛存在。该项目应用NMR(核磁共振)和MD(分子动力学)模拟来了解新亚型的这种分子识别,重要的是提供预测功能,有助于防止未来的流感流行。

An Italian R&D institution with experience in investigating the influenza A virus, is looking for partners for research cooperation agreement. The influenza A virus is widespread in bird farms with sporadic infections in humans. This project applies NMR (nuclear magnetic resonance) and MD (molecular dynamics) simulation to understand this molecular recognition for new subtypes and, importantly, provides a predictive capacity that will help forestall future influenza epidemics.

 

Description     

An Italian R&D institution is investigating the molecular mechanisms of how the protein hemagglutinin (HA) of the avian influenza A viruses recognizes the glycan host cell receptors contributing to the virus diffusion efficiency.

 

The avian influenza A virus infection begins through the binding of the viral recognition protein hemagglutinin (HA) to the glycoconjugates (glycans) of host cells. Literature data suggest that the HA of human-infective influenza subtypes preferentially recognize α(2,6) linked sialic acids (SAs) (human-like receptors), whereas the HA of avian-infective influenza sub-types preferentially recognizes α(2,3) linked SAs (avian-like receptors).  Viruses of avian origin infect and propagate between birds but rarely, and more dangerously, these zoonotic outbreaks become human adapted, carrying the threat of efficient transmission between humans; in this condition. the virus is considered potentially pandemic.

 

Advanced NMR techniques (nuclear magnetic resonance), combined with molecular dynamic simulations (MD), are essential to characterize at the molecular level, the binding between the HA of selected subtypes (H1 and H7) and host glycan receptors. The long-term goal of this study is to understand the HA recognition mechanism, focusing on the ability of different HA forms to distinguish human from avian glycan receptors, enabling prediction of those mutations that could improve HA specificity.

 

This investigation will be of interest to both academic and applied researchers, and will improve the R&D institution's ability to design new antiviral drugs. More importantly, it will provide a predictive capacity regarding which mutations of the avian virus could potentially cause human pandemics.

 

The Italian R&D institution is looking for research groups from universities and/or research institutes for research cooperation agreement.

Type and Role of Partner Sought    

Partners sought are research groups from universities and/or research institutes with strong interest in knowledge developments on the molecular mechanisms by which influenza A virus recognizes target cells.

 

The role of the partner will be to collaborate in the research project to share: knowledge, publications on international peer reviewed journals, dissemination, and application in search for funds.

【求】180041 TRIT20180619001