寻求合作
[供] 西班牙机构提供荧光纳米囊泡用于诊断测试中的成像和生物传感应用
合作类型:技术     行业类别: 生物科学与健康     国家:西班牙
发布时间:2018年08月24日     过期时间:2021年05月20日     点击数:69

西班牙加泰罗尼亚的一个研究中心拥有荧光纳米结构(<100nm)专利,适用于生物成像应用,具有卓越的稳定性和光学性能。荧光纳米囊泡通过绿色过程产生,可与双层的疏水或亲水区域相互作用,从而允许靶向应用。寻找工业合作伙伴开发对该技术感兴趣的诊断工具或造影剂,并愿通过许可协议使用。

A Catalan research center patented a fluorescent nanostructure (<100nm)  with superior stability and remarkable optical properties for bioimaging applications. The fluorescent nanovesicles are produced by a green process and can interact with the hydrophobic or  hydrophilic region of the bilayer allowing a targeted application. They are  looking for Industrial partners developing diagnostic tools or contrast agents interested in the technology and willing to use it through a license agreement.

 

Description     

A Catalan Research Center patented a new fluorescent nanostructure with superior stability and remarkable optical properties based on a nanovesicle bearing fluorescent organic dyes, irrespective of their physico-chemical and optical properties.

 

Fluorescent organic dyes are widely investigated as fluorescent probes in microscopy, thanks to their tunable optical and physicochemical properties via chemical modification of their structure.Good fluorescent probes for microscopy should be

bright and highly photostable; water soluble; and chemically stable in buffers, cell media, or body fluids; as well as capable of site-specific labeling and showing biocompatibility.

 

Delivery of hydrophobic materials in biological systems, for example contrast agents or drugs, is an obdurate challenge, severely restricting the use of materials with otherwise advantageous properties.

 

Loading an organic dye into a nonfluorescent nanocarrier, arranged as fluorescent organic nanoparticle offers an interesting strategy to bring organic dyes in aqueous media, since the obtained nanovesilces have good brightness, photostability, and biocompatibility

 

 

These fluorescent nanovesicles patented by the Catlan Research Center have been proved as efficient probes for in vivo and in vitro imaging and have potential applications in imaging, theranostic and medical applications.

 

 

The fluorescent nanovesicles can interact with the hydrophobic or the hydrophilic region of the bilayer.

 

The preparation of the fluorescent nanovesicles offers a great potential for the development of multifunctional nanovesicles integrating for example drugs, peptides and imaging agents.

 

Moreover, the fluorescent nanovesicles can incorporate simultaneously several dyes, obtaining probes for more complex applications, such as multicolor imaging. This platform is especially effective for the conveyance of non-water-soluble dyes whose optical properties are usually not stable in physiological media, but remain efficient after incorporation in nanovesicles.

 

 

The obtained nanovesicles, prepared by a CO2-based technology,show excellent colloidal- and photostability, outperforming other nanoformulations of the dyes, and improve the optical properties of the fluorophores in water.

 

Therefore, these fluorescent nanovesicles constitute an appealing nanomaterial for bioimaging applications.

The partner sought would be an Industrial company developing diagnostic tools and contrast agents interested to collaborate through a licence agreement to use this technology and bring the product to the market.

 

Type and Role of Partner Sought    

Industrial partners developing diagnostic tools, contrast agents, fluorescent probes for sensing or imaging, or theranostic formulations, are being sought to collaborate through a license agreement.

【供】180210 TOES20180525001
回复列表
1 / 共0页


发表回复:
请在下面登录后,才能发表回复
会员帐号: 密码: